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In the Office 365 portal, click Purchased Apps. Scroll down the page to find the App you downloaded. To add an App to an organization andTumor resistance to irradiation is an important cause of treatment failure in patients with cancer. The mission of the UNC Lineberger Comprehensive Cancer Center is to contribute to the understanding of the biological basis of cancer, to develop innovative technologies that will impact the treatment of cancer, and to translate these discoveries into improved patient care. The proposed Lineberger-NCI CCSG Developmental Funds application addresses a critical need in the clinical translational research enterprise. The proposed funds will support up to 15% of non-overlapping developmental research projects per year to support innovative research projects that have the potential to greatly enhance clinical outcomes for patients with cancer. Funds requested in this application reflect the highly innovative nature of the research projects proposed. These studies focus on discoveries made at the lineberger-affiliated research institutions; the funds are expected to enhance infrastructure and resources that will have a direct impact on patient care at UNC. The five projects will be supported using CCSG Developmental Funds and represent a mix of basic, translational and clinical research. These studies share a common theme; they each investigate a potential mechanism of tumor cell protection from the effects of ionizing radiation with the goal of improving cancer therapy. One study investigates the regulation of the tumor suppressor protein p53, and its phosphorylation, in response to genotoxic stress. Another study assesses the role of tumor suppressors and cell cycle regulators in the response of a broad range of hematopoietic malignancies to genotoxic agents. These are joined by studies that examine the role of microRNAs in a model of radiation-induced fibrosis in the liver, and by studies that examine the regulation of members of the E2F transcription factor family and their therapeutic potential. The translational aspects of the program arise from clinical studies that use the data generated by the basic studies to determine how these mechanisms may be targeted to enhance the clinical efficacy of radiation treatment. The five investigators’ pooled history of peer-reviewed funding for cancer research totals $12.7 million and their applications describe $3.3 million in peer-reviewed R01 and U01 grants from the NCI. The UNC Lineberger Comprehensive Cancer Center has allocated resources to enhance the administrative capabilities of these investigators including a Clinical Trials Office, a Clinical Research Network http://jonotartvnews.com/?p=23993

 

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